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Lindberg, Julia (2009) En farmakokinetisk pilotstudie av olika beredningar av bensylpenicillin intramuskulärt till häst. Other thesis, SLU.

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Abstract

Penicillin G (benzylpenicillin) is the most commonly used antimicrobial substance used in equine medicine today. Two forms of penicillin G are available for equine use; one form is the poorly soluble penicillin G procaine and the other is the very soluble sodium salt. Although penicillin has a wide safety margin and is considered to possess a good tolerance, reactions due to side effects are sometimes encountered, which commonly is named "penicillin-shock". The etiology behind penicillin shock in horses is not completely understood, but the most common reason is believed to be procaine toxicity. In order to avoid the risk of toxic reactions against procaine, penicillin G sodium can be used. In the literature contradictory information on the possibility of the usage of penicillin G sodium intramuscularly have been found. It is therefore essential to investigate the pharmacokinetics for penicillin G sodium following intramuscular injection in horse. The aim of the present study was to examine the pharmacokinetics of penicillin G following intramuscular administration of penicillin G sodium and penicillin G procaine, respectively. The investigation was a pilot study in two clinically healthy Standard bred trotters with a cross-over design and therefore each horse was given both penicillin G sodium and penicillin G procaine intramuscularly. The penicillin G dose was 11 mg/kg. The analysis of penicillin G in the horse plasma was performed by LCMSMS (liquid chromatography tandem mass spectrometry). WinNonlin was used as a tool for the pharmacological analyses, using the non-compartment method. The half-life (hours) for penicillin G sodium in the two horses was 2.55 and 2.38 respectively and for the penicillin G procain the half-life was 9.29 and 10.76. The time over MEC (minimal effective concentration in vivo) for Streptococcus equi and Streptococcus zooepidemicus lasted for both the horses in the study for at least 8 hours after penicillin G sodium were injected. The results from this study then imply that it would be possible to administer penicillin G sodium intramuscularly to horses twice a day. In order to investigate this, further tests are required.

Item Type: Thesis (Other)
Keywords: penicillin G, penicillin G sodium, penicillin G procaine, procaine, horse, penicillinchock, prokain, bensylpenicillinprokain, bensylpenicillinnatrium, bensylpenicillin, häst, benzylpenicillinprocaine, benzylpenicillinsodium
Subject (faculty): Faculty of Veterinary Medicine and Animal Science > Department of Biomedical Science and Veterinary Public Health
Divisions: SLU > Faculty of Veterinary Medicine and Animal Science
Depositing User: Julia Lindberg
Date Deposited: 10 Mar 2009
Last Modified: 18 Aug 2015 10:12
URI: http://ex-epsilon.slu.se/id/eprint/3177

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