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Andersson, Anna-Maria (2007) Osteoarthritis. Other thesis, SLU.

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Abstract

Osteoarthritis is a common and important problem in performance horses and symptoms include lameness accompanied with heat, pain and joint swelling. Several different diagnostic methods exist. However, detection of early stages of inflammation is problematic; hence assays for biochemical markers, such as the cytokines, are considered a possible way to monitor inflammation. Many of the cytokines are mediators released in the process of inflammation and one important example is tumor necrosis factor alpha (TNFα). In this pilot study of five horses, an ELISA was used to measure TNFα in synovial fluid from fetlock joints. This was performed in order to evaluate if any inflammatory reaction against intra-articularly injected hyaluronan X (hyaluronic acid) was present. Hyaluronan X is a new product with a higher molecular weight compared to hyaluronic suspensions commonly used in equine practice for the treatment of osteoarthritis. All the horses showed clinical signs of joint inflammation at some point. However, only one of the five horses presented a detectable level of TNFα in synovial fluid from the fetlock joint. Unfortunately, the hyaluronan X had been contaminated with ethanol during the manufacture and hence no conclusions about the side effects of this new hyaluronic suspension could be drawn. In future studies, a revised study design with repeated sampling of synovial fluid from experimental joints as well as control joints must be developed. In addition, the manufacturing of the hyaluronic suspension must be improved.

Item Type: Thesis (Other)
Keywords: osteoarthritis, degenerative joint disease, DJD, traumatic arthritis, equine arthritis, equine osteoarthritis, joint structure, joint function, articular cartilage, cartilage degeneration, cartilage degradation, TNFa, tumour necrosis factor, tumor necrosis factor, markers of joint disease, inflammatory mediators, mediators of inflammation, cytokine, joint treatment, medical treatment of joint disease, treatment of equine joint disease, hyaluronic acid, hyaluronan
Subject (faculty): Faculty of Veterinary Medicine and Animal Science > Department of Biomedical Science and Veterinary Public Health
Divisions: SLU > Faculty of Veterinary Medicine and Animal Science
Depositing User: Anna-Maria Andersson
Date Deposited: 01 Feb 2007
Last Modified: 18 Aug 2015 09:47
URI: http://ex-epsilon.slu.se/id/eprint/1471

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